FIELD: medicine, pharmacy.
SUBSTANCE: invention proposes a hydrophilic pharmaceutical composition with hypoglycemic effect comprising nateglinide crystals of B-type as an active component. The composition has edge angle to water surface 111 degrees or less. This edge angle is created by addition at least one hydrophilic substance to the composition chosen from groups comprising of hydrophilic polymers, surfactants, sugars and sugar-alcohols. Invention provides easy method for preparing the composition, its high solubility and rather rapid release of nateglinide.
EFFECT: improved and valuable properties of pharmaceutical composition.
13 cl, 8 dwg, 4 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NATEGLYNIDE-CONTAINING PREPARATION | 2001 |
|
RU2271805C2 |
| EASILY DOSED SOLID MEDICINAL PREPARATION | 2011 |
|
RU2574018C2 |
| SOLID PHARMACEUTICAL PREPARATION OF MATRIX TYPE | 2008 |
|
RU2465916C2 |
| EXCIPIENT FOR PROLONGATION OF DRUG RELEASE AND USING IT | 2007 |
|
RU2454222C2 |
| SOLID PHARMACEUTICAL PREPARATION OF MATRIX TYPE | 2012 |
|
RU2600797C2 |
| SOLID DOSED OUT FORMS INCLUDING FIBRAT AND STATIN | 2004 |
|
RU2343905C2 |
| PHARMACEUTICAL COMPOSITION IN SOLID FORM WITH ANALGESIC ACTIVITY | 2013 |
|
RU2545861C1 |
| METHOD FOR TREATING METABOLISM DISORDERS MAINLY DIABETES CASES AND DISEASES OR STATES RELATED TO DIABETES | 2000 |
|
RU2280447C2 |
| STABLE PERORAL GEL-FORMING PHARMACEUTICAL COMPOSITION, METHOD FOR IT PREPARING, METHOD FOR PREVENTION ALTERATION IN MEDICINAL AGENT RELEASING, METHOD FOR ENHANCEMENT OF PHYSICAL STABILITY OF PERORAL COMPOSITION | 2000 |
|
RU2220715C2 |
| AMORPHOUS ALLISARTAN ISOPROXIL, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING AMORPHOUS ALLISARTAN ISOPROXIL | 2014 |
|
RU2668267C2 |
