CYTOKINE INHIBITORS Russian patent published in 2010 - IPC C07D401/12 C07D413/14 A61K31/5377 A61K31/4427 A61P29/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts and acids. In formula (I) , Ar¹ is an aromatic carbocycle substituted with one R¹ and where Ar¹ is independently substituted with two R²; R¹ is J-N(R^a)-(CH₂)_m-, N(J)₂-(CH₂)_m-, NH₂C(O)-, J-N(R^a)-C(O)-, J-S(O)_m-N(R^a)-, J-N(R^a)-S(O)_m-; Q is CR^P; Y is -N(R^x)-; where R^a, R^p, R^x and R^y each independently denotes hydrogen or (C₁-C₅)alkyl; X is O-; W is N or CH, m independently equals 0, 1 or 2; J is selected from (C₁-C₁₀)alkyl, optionally substituted R^b; R² is selected from (C₁-C₆)alkyl or (C₁-C₄)alkoxy, optionally partially or completely halogenated; R³, R⁴ and R⁵ are each independently selected from hydrogen or (C₁-C₆)alkyl; R⁶ is optionally bonded in the ortho- or meta-position to the nitrogen atom of the said ring and is selected from a bond, -O-, O-(CH₂)_1-5-, -NH-, -C(O)-NH-, branched or straight (C₁-C₅)alkyl; and where each R₆ is further optionally covalently bonded to groups selected from hydrogen, -NR₇R₈, (C₁-C₃)alkyl, heteroaryl(C₀-C₄)alkyl, where the heteroaryl is pyrimidine, and heterocyclyl(C₀-C₄)alkyl, where the heterocyclyl is selected form morpholine, pyrrolidine, piperazinyl, optionally substituted with (C₁-C₆)alkyl; R₇ and R₈ each independently denote hydrogen or branched or straight (C₁-C₅)alkyl; and R^b is selected from hydrogen, (C₁-C₅)alkyl, amino, (C₁-C₅)alkylamino, (C₁-C₅)dialkylamino. The invention also relates to a pharmaceutical composition containing a pharmaceutically effective amount of the formula (I) compound, to use of the disclosed compounds to prepare a pharmaceutical composition and to a method of obtaining formula (I) compounds.

EFFECT: disclosed compounds have cytokine inhibiting properties.

13 cl, 3 tbl, 16 ex