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(19)

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2 284 326

(13)

(51)

IPC

C07D401/14(2006-01-01)

A61K31/4427(2006-01-01)

A61P37/02(2006-01-01)

(21) (22)

Application

2003128068/04, 2002-02-19

(24)

Start date

2002-02-19

(22)

Actual filing date

2002-02-19

(45)

Published

2006-09-27

(72)

Inventor

Laufer ShtefanKochenrojter DunjaMerkle FilippToll'Mann KarolaShtrigel' Khans-Gjunter

(73)

Holder

Merkle Gmbkh Khem.-Farm. Fabrik

2-THIO-SUBSTITUTED DERIVATIVES OF IMIDAZOLE, THEIR USING AND PHARMACEUTICAL AGENT BASED ON THEREOF Russian patent published in 2006 - IPC C07D401/14 A61K31/4427 A61P37/02

Abstract RU 2284326 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to 2-thio-substituted derivatives of imidazole of the formula (I) , their optical isomers and physiologically acceptable salts wherein R¹, R², R³ and R⁴ have values given in claim 1 of the invention. Compounds possess immunomodulating and/or inhibitory effect on cytokine release and can be useful in treatment of diseases associated with the immune system disorder. Also, invention relates to a pharmaceutical agent inhibiting release of cytokines based on compounds of the formula (I) and using these compounds for preparing a pharmaceutical agent inhibiting release of cytokines for treatment of diseases associated with the immune system disorder.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

13 cl, 1 tbl, 88 ex

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RU 2 284 326 C2

Authors

Laufer Shtefan

Kochenrojter Dunja

Merkle Filipp

Toll'Mann Karola

Shtrigel' Khans-Gjunter

Dates

2006-09-27—Published

2002-02-19—Filed