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2 285 002

(13)

(51)

IPC

C07D401/06(2006-01-01)

C07D401/14(2006-01-01)

A61K31/4427(2006-01-01)

A61K31/496(2006-01-01)

A61P11/06(2006-01-01)

C07D213/81(2006-01-01)

C07D295/04(2006-01-01)

(21) (22)

Application

2003136097/04, 2002-06-13

(24)

Start date

2002-06-13

(22)

Actual filing date

2002-06-13

(45)

Published

2006-10-10

(72)

Inventor

Ivata MasakhiroKavano NorijukiKaizava KhirojukiTakuva TomofumiTsukamoto IsseiSeo RiusiJakhiro KiesiKobajasi MikiTakeuti Makoto

(73)

Holder

Astellas Farma Ink.

DERIVATIVE OF PYRIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D401/06 C07D401/14 A61K31/4427 A61K31/496 A61P11/06 C07D213/81 C07D295/04

Abstract RU 2285002 C2

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to derivative of pyridine of the general formula (I): wherein each symbol has the following values: R¹ and R² mean hydrogen, halogen atoms, lower alkyl, lower alkoxy-group; R³ and R⁴ mean hydrogen atom, lower alkyl, halogen atom; R⁵ means hydrogen atom, lower alkyl; n = 0 or 1, or its pharmaceutically acceptable salts. Also, invention describes a pharmaceutical composition based on compounds of the formula (I) and intermediates substances used in synthesis. Compounds possess inhibitory effect on activity of phosphodiesterase of type 4.

EFFECT: valuable medicinal and biochemical properties of derivatives.

9 cl, 13 tbl, 147 ex

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RU 2 285 002 C2

Authors

Ivata Masakhiro

Kavano Norijuki

Kaizava Khirojuki

Takuva Tomofumi

Tsukamoto Issei

Seo Riusi

Jakhiro Kiesi

Kobajasi Miki

Takeuti Makoto

Dates

2006-10-10—Published

2002-06-13—Filed