TETRAHYDROPYRANYL-CYCLOPENTYL-TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Russian patent published in 2006 - IPC C07D471/04 A61K31/444 A61P29/00

Abstract RU 2285004 C2

FIELD: organic chemistry, medicine, veterinary science, pharmacy.

SUBSTANCE: invention relates to derivatives of tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridine of the formula (1): , wherein R³ means oxygen atom or absent; R⁸ is chosen from: (a) hydrogen atom; (b) (C₁-C₃)-alkyl that can be unsubstituted or substituted with 1-6 fluorine atoms; (c) -O-(C₁-C₃)-alkyl; (d) fluorine atom, and (e) hydroxy-group, and their pharmaceutically acceptable salts and separate diastereomers. These compounds are modulators of activity of chemokine receptors. Also, invention relates to a pharmaceutical composition based on compounds of the formula (1), method for modulation of activity of chemokine receptors in humans and animals and a method for preparing a medicinal agent. Invention provides preparing novel modulators of chemokine receptors activity.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

8 cl, 13 ex

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RU 2 285 004 C2

Authors

Dziao Richard

Morriehllo Gregori

Jang Likhu

Mojes Kristofer

Dates

2006-10-10—Published

2003-04-25—Filed