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2 286 343

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C2

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IPC

C07D403/06(2006-01-01)

A61K31/455(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2003107018/04, 2001-08-10

(24)

Start date

2001-08-10

(22)

Actual filing date

2001-08-10

(45)

Published

2006-10-27

(72)

Inventor

Brajtenbukher Dzh. GajKaj Kh'JuiEhdvards Dzhejms P.Grajs Cheril A.Gastin Darin Dzh.Kkhatuja KharipadaMeduna Stiven P.Pajo Barbara A.Tehjs Kevin L.Vej Dzhianmej

(73)

Holder

Orto-Maknejl Farmas'Jutikal, Ink.

SUBSTITUTED PYRAZOLES Russian patent published in 2006 - IPC C07D403/06 A61K31/455 A61P37/00 

Abstract RU 2286343 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to substituted pyrazoles of general formula I , wherein X, Y, Z are nitrogen or R12C; R1 is, halogen, alkoxy, alkyl, alkenyl, haloalkyl, cyano nitro, R9R10N, R9OC=O, R10R11NC=O or R10R11NSO2; R2 is hydrogen, halogen, alkoxy, alkyl, alkenyl, haloalkyl, cyano or R48R49N; R3, R4, R5, R6 are hydrogen or alkyl. Pharmaceutical composition and method for inhibiting of S. cathepsin also are disclosed.

EFFECT: agents useful in treatment of autoimmune diseases mediated by S. cathepsin.

43 cl, 312 ex, 3 tbl

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RU 2 286 343 C2

Authors

Brajtenbukher Dzh. Gaj

Kaj Kh'Jui

Ehdvards Dzhejms P.

Grajs Cheril A.

Gastin Darin Dzh.

Kkhatuja Kharipada

Meduna Stiven P.

Pajo Barbara A.

Tehjs Kevin L.

Vej Dzhianmej

Dates

2006-10-27—Published

2001-08-10—Filed

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