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2 317 988

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C2

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IPC

C07D471/04(2006-01-01)

C07D471/14(2006-01-01)

C07D413/14(2006-01-01)

C07D519/00(2006-01-01)

A61K31/437(2006-01-01)

A61P29/00(2006-01-01)

A61P11/06(2006-01-01)

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Application

2003107016/04, 2001-08-10

(24)

Start date

2001-08-10

(22)

Actual filing date

2001-08-10

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Published

2008-02-27

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Inventor

Batler Kristofer R.Kaj Kh'JuiEhdvards Dzhejms P.Grajs Cheril A.Gastin Darin Dzh.Kkhatuja KharipadaMeduna Stiven P.Pajo Barbara A.Sekhon Klark A.Tehjs Kevin L.Vej Dzhianmej

(73)

Holder

Orto-Maknejl Farmas'Jutikal, Ink.

SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, USING PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITION OF CATHEPSIN S ACTIVITY Russian patent published in 2008 - IPC C07D471/04 C07D471/14 C07D413/14 C07D519/00 A61K31/437 A61P29/00 A61P11/06 

Abstract RU 2317988 C2

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention describes novel substituted pyrazoles of the general formula (I): wherein values of radicals Ar, Ar2, W, G, R5-R8, RZ and n are given in the invention claim. Also, invention relates to a pharmaceutical composition based on these compounds, using this pharmaceutical composition for manufacturing agent designated for treatment of asthma, and a method for inhibition of activity of cathepsin S. Compounds indicated above can be used in medicine.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical composition.

27 cl, 3 tbl, 352 ex

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RU 2 317 988 C2

Authors

Batler Kristofer R.

Kaj Kh'Jui

Ehdvards Dzhejms P.

Grajs Cheril A.

Gastin Darin Dzh.

Kkhatuja Kharipada

Meduna Stiven P.

Pajo Barbara A.

Sekhon Klark A.

Tehjs Kevin L.

Vej Dzhianmej

Dates

2008-02-27—Published

2001-08-10—Filed

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