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(19)

(11)

2 286 388

(13)

(51)

IPC

C12N15/12(2006-01-01)

C07K14/47(2006-01-01)

C12N1/21(2006-01-01)

C12N5/10(2006-01-01)

(21) (22)

Application

99102976/13, 1999-02-11

(24)

Start date

1989-05-25

(22)

Actual filing date

1999-02-11

(45)

Published

2006-10-27

(72)

Inventor

Khehnnon Charl'Z Kh.Ajzenberg Stefen P.Tompson Robert S.Arend Vil'Jam P.Dzhoslin Fenneke G.Sommer Andreas

(73)

Holder

Amgen Ink.Dze Ridzhents Of Dze Juniversiti Of Kolorado

INTERLEUKIN-1 INHIBITOR, METHOD FOR PRODUCTION THEREOF, DNA MOLECULE ENCODING INTERLEUKIN-1 INHIBITOR, AND PRECURSOR THEREOF Russian patent published in 2006 - IPC C12N15/12 C07K14/47 C12N1/21 C12N5/10

Abstract RU 2286388 C2

FIELD: biotechnology, gene engineering, medicine.

SUBSTANCE: polypeptide (IL-li) is obtained by recombinant DNA technology having activity of interleukin-1-alpha and interleukin-1-beta inhibitor. Disclosed is DNA sequences encoding inhibitor precursor and maturated form thereof. Described is method for production of vector constructs containing said DNA sequences, as well as transformed cells producing of recombinant IL-li.

EFFECT: method for large-scale production of interleukin-1-beta inhibitor, useful in medicine.

21 cl, 26 dwg, 11 ex

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RU 2 286 388 C2

Authors

Khehnnon Charl'Z Kh.

Ajzenberg Stefen P.

Tompson Robert S.

Arend Vil'Jam P.

Dzhoslin Fenneke G.

Sommer Andreas

Dates

2006-10-27—Published

1999-02-11—Filed