FIELD: biotechnology.
SUBSTANCE: present invention refers to recombinant vector systems expressing therapeutic proteins, and can be used in medicine for treating inflammation. A method of treating inflammation in a subject comprises expressing one or more vectors of interleukin 10 (IL-10) peptide and interleukin 10 type 1 receptor peptide (IL-10R1) in antigen-representing cells in a subject. Also disclosed is a single viral or bacterial expression vector comprising coding regions for IL-10 and IL-10R1.
EFFECT: invention provides overcoming the dose-dependent down regulation of IL-10 by expressing IL-10R1 peptide in addition to the IL-10 peptide.
31 cl, 4 dwg, 7 ex
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