FIELD: medicine.
SUBSTANCE: invention relates to biotechnology. Described is hybrid protein, including signal peptide, EGF-repetitions of 1-X extracellular domain of human Notch3 receptor protein, with X being any integer number from 1 to 10 or 12 to 33, and bound to them Fc-part of antibody. Also described are method of treating tumour-affected subject, method of inhibiting angiogenesis in subject, method of treating subject with ovarian cancer, and method of treating subject with metabolic disorder. Methods include introduction of said hybrid protein to subject in efficient quantity. In addition disclosed is application of said hybrid protein for preparation of pharmaceutical composition for treating tumour-affected subject, for inhibition of angiogenesis in subject, for treatment of subject with ovarian cancer and for treatment of subject with metabolic disorder.
EFFECT: claimed group of inventions can be used in medicine.
21 cl, 93 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS OF HUMANISED NOTCH FUSED PROTEINS AND METHODS OF TREATING | 2008 |
|
RU2532830C2 |
| NUCLEOTIDE SEQUENCE ENCODING FUSED PROTEIN CONSISTING OF SOLUBLE EXTRACELLULAR FRAGMENT OF HUMAN Dll4 AND CONSTANT PART OF HEAVY CHAIN OF HUMAN IgG4 | 2021 |
|
RU2787060C1 |
| AGONIST NOTCH3 ANTIBODIES AND APPLICATION THEREOF FOR TREATING NOTCH3-ASSOCIATED DISEASES | 2007 |
|
RU2461569C2 |
| THERAPEUTIC METHODS OF VASCULAR EYE DISEASE TREATMENT WITH Dll4 ANTAGONISTS | 2007 |
|
RU2429876C2 |
| METHODS FOR TREATING MALIGNANT TUMOUR WITH APPLICATION OF NOTCH SIGNAL TRANSDUCTION PATHWAY INHIBITORS | 2008 |
|
RU2584579C2 |
| ANTIBODIES-ANTAGONISTS AGAINST Notch3 AND THEIR APPLICATION FOR PREVENTION AND TREATMENT OF Notch3-RELATED DISEASES | 2007 |
|
RU2493167C2 |
| ANTI-NOTCH1 ANTIBODIES | 2011 |
|
RU2622083C2 |
| NRR Notch1 ANTIBODIES AND METHODS OF APPLICATION THEREOF | 2008 |
|
RU2476443C2 |
| PEPTIDES OF DIRECTED ACTION OF VEGFR-1/NRP-1 | 2008 |
|
RU2488592C2 |
| ANTIBODIES AGAINST NOTCH2 AND METHODS FOR APPLICATION THEREOF | 2009 |
|
RU2580029C2 |
