DERIVATIVES OF HETEROARYL-SUBSTITUTED AMINOCYCLOHEXANE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D213/74 C07D237/20 C07D241/26 C07D239/42 C07D401/04 C07D401/14 C07D409/04 C07D409/14 A61K31/495 A61K31/44 A61K31/4965 A61K31/445 A61K31/497 A61K31/50 A61K31/501 A61K31/505 A61K31/506 A61P3/00 

FIELD: organic chemistry, chemical technology, biochemistry, pharmacy.

SUBSTANCE: invention relates to novel derivatives of heteroaryl-substituted aminocyclohexane of the formula (I) and their pharmaceutically acceptable salts possessing the inhibitory effect on activity of 2,3-oxydosqualene-lanosterolcyclase (OSC). In the formula (I) V means a simple bond, oxygen atom (O), -CH=CH-CH₂- or -C≡C-; m and n = 0-7 independently of one another and m+n = 0-7 under condition that m is not 0 if V means O; o = 0-2; A¹ means hydrogen atom, lower alkyl, hydroxy-lower alkyl or lower alkenyl; A² means lower alkyl, or A¹ and A² are bound and form 5-6-membered cycle, and -A¹-A²- means (C₄-C₅)-alkylene; A³ and A⁴ mean hydrogen atom independently of one another; A⁵ means hydrogen atom, lower alkyl; A⁶ means pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl optionally substituted with one substitute chosen independently from the group including halogen atom, lower alkyl, lower alkoxy-group and 5-6-membered heteroaryl comprising nitrogen or sulfur atom as a heteroatom, Also, invention relates to a pharmaceutical composition and using proposed compound for preparing medicinal agents. Proposed compounds can be used in treatment of such diseases as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycosis, parasitic infections, cholelithiasis, tumors and/or hyperproliferative disorders, and/or in disordered tolerance to glucose and diabetes mellitus.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

24 cl, 7 sch, 28 ex