DERIVATIVES OF 1,2-DIAMINOPENTANE AS ANTAGONISTS OF CCR-3 RECEPTORS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D239/38 C07C233/79 C07C233/41 C07C275/36 A61K31/166 A61K31/17 A61K31/505

Abstract RU 2286339 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of 1,2-diaminopentane of the formula (I): wherein R₁ means hydrogen atom, (C₁-C₆)-alkyl; R₂ means phenyl-(C₁-C₆)-alkyl wherein phenyl is substituted with halogen atom; R₃ means hydrogen atom; R₄ means -W-X-Y-Z wherein W is absent or means (C₁-C₆)-alkylene; X is absent or means -S(O)_n- or -N(R_a)-; Y means arylene or heteroarylene; Z means hydrogen atom, aryl; R_a means hydrogen atom; n = 0 under condition that this enumeration doesn't involve trans-3,4-dichloro-N-[2-(dimethylamino)cyclopentyl]benzamide and trans-N-methyl-3,4-dichloro-N-[2-(dimethylamino)cyclopentyl]benzamide, or its pharmaceutically acceptable salt. Also, invention proposes a pharmaceutical composition possessing antagonistic activity with respect to CCR-3 receptors and comprising the effective amount of compound of the formula (I) or its salt and excipient. Invention provides using derivatives of 1,2-diaminopentane inhibiting binding eotaxine with CCR-3 receptors.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

27 cl, 1 tbl, 17 ex

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RU 2 286 339 C2

Authors

Dju-Bua Dejsi Dzho

Dates

2006-10-27—Published

2002-09-05—Filed