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(19)

(11)

2 286 988

(13)

(51)

IPC

C07D231/06(2006-01-01)

C07D401/12(2006-01-01)

C07D401/04(2006-01-01)

C07D409/04(2006-01-01)

A61K31/415(2006-01-01)

A61K31/4155(2006-01-01)

A61K31/4439(2006-01-01)

A61K31/454(2006-01-01)

A61K31/4725(2006-01-01)

A61K31/5377(2006-01-01)

A61K31/496(2006-01-01)

A61K31/55(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2003130268/04, 2002-09-17

(24)

Start date

2002-09-17

(22)

Actual filing date

2002-09-17

(45)

Published

2006-11-10

(72)

Inventor

Krjuse Kornelis G.Lange Jozefus Kh.M.Tipker JakobusKherremans Arnol'Dus Kh.J.Van Stejvenberg Kherman Kh.

(73)

Holder

Solvej Farmas'Jutikals B.V.

DERIVATIVES OF 4,5-DIHYDRO-1H-PYRAZOLE POSSESSING STRONG CB1-ANTAGONISTIC ACTIVITY Russian patent published in 2006 - IPC C07D231/06 C07D401/12 C07D401/04 C07D409/04 A61K31/415 A61K31/4155 A61K31/4439 A61K31/454 A61K31/4725 A61K31/5377 A61K31/496 A61K31/55 A61P25/00

Abstract RU 2286988 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a group of novel derivatives of 4,5-dihydro-1H-pyrazole that are strong antagonists of cannabinoid (CB₁) receptor and useful in treatment of diseases associated with disorders of cannabinoid system. Compounds have the general formula (Ia) or (Ib) wherein symbols are given in the invention claim. Also, invention relates to method for synthesis of these compounds, their using, intermediate compounds for synthesis of proposed compounds and to a pharmaceutical composition comprising at least one of these compounds as an active component.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

15 cl, 1 tbl, 100 ex

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RU 2 286 988 C2

Authors

Krjuse Kornelis G.

Lange Jozefus Kh.M.

Tipker Jakobus

Kherremans Arnol'Dus Kh.J.

Van Stejvenberg Kherman Kh.

Dates

2006-11-10—Published

2002-09-17—Filed