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(19)

RU

(11)

2 357 958

(13)

C2

(51)

IPC

C07D233/90(2006-01-01)

A61K31/4164(2006-01-01)

A61K31/4166(2006-01-01)

A61P5/00(2006-01-01)

A61P11/06(2006-01-01)

A61P25/00(2006-01-01)

A61P25/16(2006-01-01)

A61P25/28(2006-01-01)

A61P1/00(2006-01-01)

A61P15/00(2006-01-01)

(21) (22)

Application

2006133373/04, 2005-02-16

(24)

Start date

2005-02-16

(22)

Actual filing date

2005-02-16

(45)

Published

2009-06-10

(72)

Inventor

Lange Jozefus Kh. M.Kruse Kornelis G.Van Stejvenberg Kherman Kh.

(73)

Holder

Solvej Farmas'Jutikals B.V.

IMIDAZOLINE DERIVATIVES HAVING CB-ANTAGONIST ACTIVITY Russian patent published in 2009 - IPC C07D233/90 A61K31/4164 A61K31/4166 A61P5/00 A61P11/06 A61P25/00 A61P25/16 A61P25/28 A61P1/00 A61P15/00 

Abstract RU 2357958 C2

FIELD: chemistry.

SUBSTANCE: invention refers to imidazoline derivatives having CB1-antagonist activity of general formula where: R1 and R2 independently stand for phenyl which can be substituted with 1-2 substitutes Y being identical and represent chlorine, bromine, fluorine, iodine, X stands for one subgroup or , where: R3 stands for hydrogen atom or linear C1-3 alkyl group, R4 stands for C3-8 cycloalkyl or C5-10, and said groups can contain one atom N, R7 represents benzyl or phenyl group, and specified groups can be substituted in aromatic ring by 1 substitute Y, where Y is evaluated as specified above being either identical, or different, or R7 stands for C1-8dialkylaminogroup, R8 represents hydrogen atom, R9 represents hydrogen atom and their salt. Additionally, the invention concerns a pharmaceutical composition based on compound of formula I, and to its application for therapy of diseases caused by canabiod neurotransmission.

EFFECT: new compounds possess useful biological activity.

9 cl, 1 tbl, 3 ex

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RU 2 357 958 C2

Authors

Lange Jozefus Kh. M.

Kruse Kornelis G.

Van Stejvenberg Kherman Kh.

Dates

2009-06-10—Published

2005-02-16—Filed

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