NOVEL TETRAZOLONE DERIVATIVES Russian patent published in 2018 - IPC C07D257/04 C07D401/04 C07D401/06 C07D401/12 C07D403/06 C07D403/14 C07D413/06 C07D413/14 C07D417/06 C07D491/107 A61K31/41 A61K31/4439 A61K31/454 A61K31/496 A61K31/5377 A61P25/00 

Abstract RU 2664644 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), wherein R1 is n-propyl, iso-butyl, cyclopropyl, 3-fluorophenyl, 6-chloropyridin-3-yl, 3-chlorophenyl, 4-chlorophenyl, 3-trifluoromethoxyphenyl, 2-(trifluoromethyl)phenyl, 3-(trifluoromethyl)phenyl, 4-(trifluoromethyl)phenyl, 2,6-difluorophenyl, 2,5-difluorophenyl, 3,4-difluorophenyl, 3,5-difluorophenyl, 3-methylphenyl, 4-methylphenyl, 3-methoxyphenyl, 4- methoxyphenyl, 2,3-dichlorophenyl, 1-methylindolyl or 3-bromophenyl; R2 is -C(O)NR3R4 or R5; the values of the remaining substituents are indicated in the claims. Invention also relates to a pharmaceutical composition having the activity of a cannabinoid receptor 2 (CB2) agonist. .

EFFECT: technical result: obtaining novel compounds of formula (I), which can be used as a therapeutically active substance, which is a cannabinoid receptor 2 (CB2) agonist.

14 cl, 142 ex

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RU 2 664 644 C2

Authors

Greter Uve

Nettekofen Mattias

Pyullmann Bernd

Refer Shtefan

Rodzhers-Evans Mark

Shults-Gash Tanya

Dates

2018-08-21Published

2014-06-04Filed