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RU

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2 360 904

(13)

C2

(51)

IPC

C07D231/06(2006-01-01)

A61K31/415(2006-01-01)

A61K31/454(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2006131132/04, 2005-01-27

(24)

Start date

2005-01-27

(22)

Actual filing date

2005-01-27

(45)

Published

2009-07-10

(72)

Inventor

Lange Jozefus Kh.M.Krjuse Kornelis G.Van Stejvenberg Kherman Kh.

(73)

Holder

Solvej Farmas'Jutikals B.V.

1,3,5-TRISUBSTITUTED DERIVATIVES OF 4,5-DIHYDRO-1H-PYRAZOLE, POSSESSING CB-ANTAGONISTIC ACTIVITY Russian patent published in 2009 - IPC C07D231/06 A61K31/415 A61K31/454 A61P25/00 

Abstract RU 2360904 C2

FIELD: chemistry; medicine.

SUBSTANCE: invention relates to 1,3,5-trisubstituted derivatives of 4,5-dihydro-1H pyrazole of general formula (I) , in which symbols have values given in i.1 of invention formula, based on them pharmaceutical composition, novel intermediate compounds suitable for synthesis of said pyrazole derivatives. Compounds of formula (I) are antagonists of cannabinoid receptors CB1. Invention also relates to the application of formula (I) compounds for obtaining medications for treatment of group of diseases mediated by CB1, such as psychosis, anxieties, depression, memory impairments, food intake disorders, etc.

EFFECT: increased efficiency of composition and treatment method.

7 cl, 1 tbl, 3 ex

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RU 2 360 904 C2

Authors

Lange Jozefus Kh.M.

Krjuse Kornelis G.

Van Stejvenberg Kherman Kh.

Dates

2009-07-10—Published

2005-01-27—Filed

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