METHOD FOR OBTAINING 10%-CALCIUM GLUCONATE SOLUTION FOR INJECTIONS Russian patent published in 2006 - IPC A61K31/191 A61K9/08 

FIELD: pharmaceutics.

SUBSTANCE: the present innovation deals with the technique to prepare 10%-calcium gluconate solution for injections including dissolving the substance, filtration, pouring and sterilizing; moreover, the substance should be pre-mixed at about 10-30° C with aqueous solution of hydrogen peroxide at concentration ranged 0.00015-0.15% to be kept for about 4-24 h; the mixture should be dissolved in water at 70-90° C to be heated up to 100 C, not more and kept at pressure (0.5±0.02) MPa for 20 min, not less, then solution should be poured into the ampoules and sterilized with flowing steam at 100 C, not more for 1 h, not more. The innovation enables to obtain a stable and noncaramelizing and noncrystalizing solution of calcium gluconate.

EFFECT: higher efficiency.

3 ex, 3 tbl