DERIVATIVES OF POLYETYLENE GLYCOL ALDEHYDE Russian patent published in 2006 - IPC C07C47/12 C07C47/198 C08G65/329 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to compounds of polyethylene glycol aldehyde (PEG-aldehydes), to method for synthesis of indicated compounds of polyethylene aldehyde, and to intermediate compounds that are used in synthesis of PEG-aldehydes. Method for synthesis of PEG-aldehydes involves pyrolysis of indicated intermediate substances. Indicated aldehydes of polyethylene glycols represent specific reagents for formation of PEG-peptides and other biomolecules by N-terminal amino acid residues, i. e. PEG-aldehydes form conjugate with N-terminal α-amino-group of biomolecule or protein with formation of a stable bond as secondary amine between PEG and biomolecule or protein. Also, in PEG-polypeptides the specific N-terminal bond is formed that excludes formation of cross-linking bonds or formation of some derivatives of the same polypeptide. Depending on chosen aldehyde PEG can bind covalently with biomolecule by one terminal group (monofunctional PEG-aldehyde) or by two terminal groups (bifunctional PEG-aldehyde). The advantage of PEG conjugates with biomolecules involves their enhanced retaining and delayed metabolism in body.

EFFECT: improved preparing method, improved and valuable properties of compounds.

17 cl, 7 ex