GATIFLOXACIN FORMULATIONS FOR USING IN PEDIATRICS Russian patent published in 2006 - IPC C07C215/56 C07D401/04 A61K45/08 

FIELD: medicine, pediatrics, pharmacy.

SUBSTANCE: invention relates to formulation of antibacterial preparation gatifloxacin prepared as a crystalline combined sediment of gatifloxacin and fatty acid. Method involves dissolving gatifloxacin and fatty acid in the weight ratio from 1:1.8 to 1:2.3 in solvent at heating up to boiling with reflux condenser, boiling this solution with reflux condenser for 2-3 h at stirring, cooling this solution at stirring to temperature about 18°C for 2.5-4 h to precipitate of crystalline combined sediment of gatifloxacin and fatty acid, keeping the prepared suspension of crystalline combined sediment at temperature 15-20°C for 2-4 h and isolating and drying the crystalline combined sediment. Also, invention describes a pharmaceutical composition used in treatment of infections and a method for treatment of infection by using the novel formulation of gatofloxacin. Crystalline combined sediment of gatifloxacin with stearic or palmitic acids taken in the narrow range of weight ratios masks bitter taste of gatifloxacin effectively.

EFFECT: improved preparing method, improved and valuable pharmaceutical properties of drug.

10 cl, 2 ex