DIRECTLY PRESSED MATRIX FOR REGULATED RELEASE OF SINGLE DAILY CLARITHROMYCIN DOSES Russian patent published in 2004 - IPC

FIELD: medicine.

SUBSTANCE: the suggested peroral solid medicinal form for regulated release of single daily clarithromycin doses is applied at treating and preventing bacterial infections. Medicinal form contains clarithromycin and new combined matrix out of the mixture of fatty and hydrophilic components. The content of fatty component corresponds to 10-36% against tablet's weight. The content of hydrophilic component corresponds to 5-18% against tablet's weight. Medicinal form could additionally contain surface-active substance and pH modulator. It has been elaborated a simple, efficient and pH-independent ready-to-use form of clarithromycin macrolide antibiotic. It provides reproducible release of clarithromycin during 24 h at minimization of subjective impact onto each patient individually.

EFFECT: higher efficiency of regulation.

14 cl, 2 dwg, 6 ex