PROPOSED 3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS Russian patent published in 2024 - IPC C07D471/04 A61K31/4375 A61P35/00 

FIELD: organic chemistry.

SUBSTANCE: group of inventions includes a compound of formula I, a compound of formula II, 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them, method of treatment and use based on 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione. In formula I R¹ represents H, Br, C1-C6 alkyl or phenyl; R² is H, halogen or CH₃-; R³ is H, hydroxyC1-C6 alkyl-, hydroxyC1-C6 alkoxy-, C1-C6 alkoxy, fluoroC1-C6 alkoxy, C3-C6 cycloalkyl or (C3-C6 cycloalkyl)C1-C6 alkoxy-; R⁴ is phenyl substituted with 1, 2 or 3 substituents, independently selected from halogen, C1-C6 alkyl, C1-C6 alkylthio, fluoroC1-C6 alkylthio, fluoroC1-C6 alkyl, C1-C6 alkoxy, fluoroC1-C6 alkoxy, C3-C6 cycloalkyl and C1-C6 alkyl-C(=O)-. In formula II, R¹ is H, Br, C1-C6 alkyl or phenyl; R² is H, halogen or CH₃-; R³ is H, hydroxyC1-C6 alkyl-, hydroxyC1-C6 alkoxy-, C1-C6 alkoxy, fluoroC1-C6 alkoxy, C3-C6 cycloalkyl or (C3-C6 cycloalkyl)C1-C6 alkoxy-; R^a and R^b are independently selected from halogen, C1-C6 alkyl, C1-C6 alkylthio, fluoroC1-C6 alkyl, C1-C6 alkoxy, fluoroC1-C6 alkoxy, C3-C6 cycloalkyl and C1-C6 alkyl-C(=O)-.

EFFECT: derivatives of 3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione, having MEK inhibitory activity.

36 cl, 5 dwg, 8 tbl, 77 ex