HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND THEIR USING Russian patent published in 2006 - IPC C07D401/14 C07D413/14 C07D417/14 C07D403/14 C07D405/14 C07D401/12 A61K31/47 A61P31/18 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to compounds of the formula (1):

and their salts wherein ring A comprises optionally heteroatom oxygen (O); dotted lines represent the optional unsaturation; R¹ represents (C₁-C₄)-alkoxy-group; R² and R³ represent independently hydrogen atom (H), optionally halogenated (C₁-C₄)-alkyl, optionally substituted aromatic group, or R² and R³ in common can form substituted or unsubstituted 5-7-membered ring condensed with ring E; k = 0-4; L¹ represents a covalent bond or (C₁-C₆)-alkyl optionally comprising nitrogen atom (N); X represents unsubstituted or substituted carbon © atom or N, or represents O or sulfur (S) atom; Ar represents phenylene; each n = 0-2 independently; each R represents independently H or (C₁-C₆)-alkyl; Y represents optionally substituted aromatic or heteroaromatic group or 5-11-membered heterocyclic group comprising 1-4 heteroatoms cgosen from N, O and S that are bound with chemokine receptors comprising CXCR4 and CCR5, and elicit the protective affect against damage of host-cells by human immunodeficiency virus (HIV).

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.