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(19)

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2 309 741

(13)

(51)

IPC

A61K31/395(2006-01-01)

A61K35/14(2006-01-01)

A61K35/28(2006-01-01)

(21) (22)

Application

2004105961/15, 2002-07-30

(24)

Start date

2002-07-30

(22)

Actual filing date

2002-07-30

(45)

Published

2007-11-10

(72)

Inventor

Bridzher Gari Dzh.Ehbrams Majkl Dzh.Khenson Dzheffri V.Makfarlehnd Ronal'D TrevorKalandra Gari B.Dejl Devid S.Broksmejer Khel Eh.

(73)

Holder

Anormed Ink.

METHODS FOR ACTIVATION OF CELLS-PRECURSORS/STEM CELLS Russian patent published in 2007 - IPC A61K31/395 A61K35/14 A61K35/28

Abstract RU 2309741 C2

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to using compound of the formula Z-linker-Z' (1) representing antagonist of chemokinine receptor CXCR4 for preparing a medicinal agent used in mobilization and collection of cell-precursors and/or stem cells in subject. The claimed invention describes also methods for increasing amount of cell-precursors and stem cells in animals using compounds that bind chemokinine receptor CXCR4. Using compound of the formula (1) allows enhancing effectiveness in treatment of HIV and to alleviate unfavorable effects on bone marrow in the process of chemotherapy carrying out.

EFFECT: improved methods for activation.

19 cl, 12 tbl, 1 dwg, 4 ex

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RU 2 309 741 C2

Authors

Bridzher Gari Dzh.

Ehbrams Majkl Dzh.

Khenson Dzheffri V.

Makfarlehnd Ronal'D Trevor

Kalandra Gari B.

Dejl Devid S.

Broksmejer Khel Eh.

Dates

2007-11-10—Published

2002-07-30—Filed