IMPROVED RELEASE PROFILE MICROPARTICLES AND METHOD FOR PRODUCING THE PARTICLES Russian patent published in 2007 - IPC A61K9/16 A61K9/40 A61K47/30 

FIELD: medicine.

SUBSTANCE: method involves a) adding composition containing active substance, to organic polymer solution and dispersing in it; b) adding emulsion or dispersion produced at staged a) to external phase and dispersed in it, the external phase having temperature of 0 to 20°C at the moment of adding, external phase being like aqueous solution or oil phase containing emulsifying agent and/or protection colloid; c) removing organic solvent to subject emulsion or dispersion produced at stage b), to pressure action less than less than 1000 mbar or introducing inert gas into emulsion or dispersion produced at stage b). Micro particles produced in this way possess favorable properties. Active substance quantity released during flash stage, is insignificant, but total release volume is high. Active substance release lasts several weeks or months.

EFFECT: enhanced effectiveness of treatment; slow release of active substance.

25 cl, 8 dwg, 1 tbl