FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to using compound of the formula (I) 
as the first anti-tumor agent for preparing a medicinal preparation that in administration with the second anti-tumor agent prevents development of resistance of malignant cells to apoptosis as result of activation of NFKB by the indicated second anti-tumor agent. Invention provides enhancing effectiveness of treatment.
EFFECT: improved and valuable medicinal properties of agent.
15 cl, 4 tbl, 3 ex
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