Show metadata Hide metadata

(19)

(11)

2 292 342

(13)

(51)

IPC

C07D401/12(2006-01-01)

A61K31/4427(2006-01-01)

A61P1/04(2006-01-01)

(21) (22)

Application

2005105564/04, 2003-07-15

(24)

Start date

2003-07-15

(22)

Actual filing date

2003-07-15

(45)

Published

2007-01-27

(72)

Inventor

Sehchs DzhorzhShin Dzhej MuGarst Majkl E.

(73)

Holder

Uinston Farmas'Jutikals Lls.Regentskij Sovet Universiteta KaliforniiPravitel'Stvo Ssha V Litse Departamenta Po Delam Veteranov

DERIVATIVES OF BENZIMIDAZOLE AND THEIR USING AS PRODRUGS OF PROTON PUMP INHIBITORS Russian patent published in 2007 - IPC C07D401/12 A61K31/4427 A61P1/04

Abstract RU 2292342 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formulas (1) , (2) , (3) or (4) , or isomers of compounds of formulas (2) and (3) wherein symbol values are determined in the invention claim. Also, invention relates to their pharmaceutically acceptable salts showing the improved solubility in aqueous media and improved bioavailability wherein indicated compounds possess the inhibitory activity with respect to secretion of gastric acid.

EFFECT: valuable medicinal properties of compounds.

35 cl, 44 sch, 4 tbl, 165 ex

Similar patents RU2292342C2

Title	Year	Author	Number
PYRIDINE DERIVATIVES	1992	Sigeru Souda[Jp] Norikhiro Ueda[Jp] Sikhei Mijazava[Jp] Katsuja Tagami[Jp] Seitiro Nomoto[Jp] Makoto Okita[Jp] Naojuki Simomura[Jp] Tosikhiko Kaneko[Jp] Masatosi Fudzimoto[Jp] Manabu Murakami[Jp] Kiesi Oketani[Jp] Khideaki Fudzikava[Jp] Khisasi Sibata[Jp] Tsuneo Vakabajasi[Jp]	RU2035461C1
DERIVATIVES OF BENZIMIDAZOLE AND PHARMACEUTICAL COMPOSITIONS COMPRISING PRODRUG OF PROTON PUMP INHIBITOR	1999	Gehrst Majkl E. Sehchs Dzhorzh Shin Dzhej Mu	RU2232159C2
SUBSTITUTED SULFONEAMIDES, SUBSTITUTED CYCLIC AMINES AS INTERMEDIATE COMPOUNDS FOR THE SYNTHESIS OF THE SUBSTITUTED SULFONEAMIDES AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO THROMBOXANE A2 RECEPTORS	1991	Klod Lardi[Fr] Daniel' Gerr'E[Fr] Zhil' Shavernak[Fr] Fransua Kollonzh[Fr]	RU2096404C1
CARBOXYLIC ACID DERIVATIVES	1995	Khartmut Rikhers Dagmar Klinge Vil'Khel'M Amberg Andreas Kling Shtefan Mjuller Ehrnst Baumann Joakhim Rajnkhajmer Uve Jozef Fogel'Bakher Vol'Fgang Vernet Liliane Unger Manfred Rashak	RU2180335C2
AMINOPYRAZOLE DERIVATIVE	2010	Naoki Taka Masayuki Omori Keko Takami Masayuki Matsushita Tadakatsu Khayase Ikume Khedo Masami Kochi Khiroki Nishii Khirosato Ebiike Joshito Nakanishi Toshiyuki Mio Lisha Van Vejli Chzhao	RU2580543C9
DERIVATIVES OF ALPHA-(N-SULFONAMIDO)ACETAMIDE AS INHIBITORS OF BETA-AMYLOID	2002	Parker Majkl F. Mkelkhon Kehterin E. Meht Robert A. Bronson Dzhoann Dzh. Gaj Jungkhua Bergstrom Karl P. Markin Lourens R. Mehkor Dzhon E.	RU2300518C2
METHOD OF OBTAINING DERIVATIVES OF IMIDAZOLE OR THEIR SALTS WITH ACIDS	0	Albert Fishli Anna Krasso Khenri Ramuts Andre Sente	SU1362402A3
NOVEL PYRIDINE DERIVATIVES, WHICH POSSESS ANTI-HELICOBACTER PYLORY ACTIVITY	2007	Ito Masakharu Jamamoto Masaiti	RU2433126C2
1-SULFONYL-1,3-DIHYDROINDOLE-2-ONES, PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHOD FOR THEIR PREPARING AND APPLYING	2003	Ivashchenko A.V. Khvat Aleksandr Viktorovich Kravchenko D.V. Tkachenko S.E. Okun' Il'Ja Matusovich	RU2259999C2
DERIVATIVES OF SUBSTITUTED BENZOYLBENZENE-, BIPHENYL OR 2-OXAZOLEALKANOIC ACID OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, AND A METHOD OF THEIR SYNTHESIS	1992	Amedeo Arturo Fejlli[Us] Ehntoni Frehnk Kreft Iii[Us] Dzhon Genri Musser[Us]	RU2037481C1

RU 2 292 342 C2

Authors

Sehchs Dzhorzh

Shin Dzhej Mu

Garst Majkl E.

Dates

2007-01-27—Published

2003-07-15—Filed