DERIVATIVES OF SUBSTITUTED BENZOYLBENZENE-, BIPHENYL OR 2-OXAZOLEALKANOIC ACID OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS, AND A METHOD OF THEIR SYNTHESIS Russian patent published in 1995 - IPC

Abstract RU 2037481 C1

FIELD: organic chemistry. SUBSTANCE: products: derivatives of substituted benzoyl-, biphenyl- or 2-oxazolealkanoic acid of the formula (I) A(CH2)nO-B where A a group of the formula (I) where X-N- or C(R3)- - or -S- at condition that when C(R3)-- Z or lower alkyl then n 1-2; B a group of the formulas II, III, IV, V where R4, R5, R6, R7, m have corresponding meanings, or their salts. Compounds of the formula (I) were synthesized by interaction of compound of the formula HO2-B with compound of the formula A(CH2)n-X where X splitting off group. Synthesized compounds were used in medicine as leucotriene antagonists and lipoxygenase inhibitors. EFFECT: improved method of synthesis. 11 cl, 6 tbl

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RU 2 037 481 C1

Authors

Amedeo Arturo Fejlli[Us]

Ehntoni Frehnk Kreft Iii[Us]

Dzhon Genri Musser[Us]

Dates

1995-06-19Published

1992-04-24Filed