FIELD: medicine, virology, biochemistry.
SUBSTANCE: invention relates to a method for inhibition of viruses growth and/or virulicide effect. Method involves biotransformation of pyrazine nucleotide analog of the formula [2] 
and pyrazine nucleoside analog of the formula [3z] 
involving decomposition and phosphorylation resulting to preparing analog of pyrazine nucleotide of the formula [1b] 
and above said effect. This method can be used as a method for treatment of viral infections. Also, analog of pyrazine carboxamide or its salt can be used as an agent for prophylaxis and treatment of viral infections. Invention provides the development of a novel anti-viral agent and methods for its using.
EFFECT: valuable medicinal properties of analogs, improved method for inhibition.
50 cl, 80 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF PYRAZINE OR THEIR SALTS, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING | 2001 |
|
RU2297414C2 |
| DERIVATIVES OF PYRAZINE AND THEIR SALTS, PHARMACEUTICAL COMPOSITION COMPRISING THESE COMPOUNDS | 2001 |
|
RU2259368C2 |
| NOVEL PHENYL PYRROLE DERIVATIVE | 2009 |
|
RU2470917C2 |
| SYNTHETIC INTERMEDIATE COMPOUND 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE THIONUCLEOSIDES COMPOUND AND METHOD FOR THEIR PRODUCTION | 2013 |
|
RU2633355C2 |
| NEW PHOSPHORAMIDATE NUCLEOSIDE DERIVATIVES AND APPLICATION THEREOF | 2014 |
|
RU2621709C2 |
| NEW 2-HETEROARYL-SUBSTITUTE BENZIMIDAZOLE DERIVATIVE | 2004 |
|
RU2329261C2 |
| MACROHETEROCYCLIC NUCLEOSIDE DERIVATIVES AND ANALOGUES THEREOF, PRODUCTION AND USE | 2017 |
|
RU2731385C1 |
| 2-PYRIDONE DERIVATIVES | 2010 |
|
RU2551847C2 |
| NOVEL CYCLOHEXANE DERIVATIVE, PRODRUG AND SALT THEREOF AND DIABETES THERAPEUTIC AGENT CONTAINING SAID COMPOUNDS | 2005 |
|
RU2394015C2 |
| NEW PYRROLOPYRIMIDINE COMPOUND OR ITS SALT, PHARMACEUTICAL COMPOSITION CONTAINING IT, IN PARTICULAR, AGENT FOR PREVENTION AND / OR TREATMENT OF TUMORS AND SO ON, BASED ON INHIBITING INFLUENCE ON NAE | 2015 |
|
RU2658008C2 |
