DERIVATIVES OF PYRAZINE OR THEIR SALTS, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING Russian patent published in 2007 - IPC C07D405/04 A61K31/496 A61P31/12 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of pyrazine of the general formula (I): and their salts wherein R¹ represents hydrogen atom or halogen atom; R² represents hydrogen atom or protected or unprotected group of monophosphoric, diphosphoric or triphosphoric acid; R³, R⁴, R⁵ and R⁶ can be similar or different and represent hydrogen atom, halogen atom, substituted or unsubstituted, protected or unprotected hydroxyl group or amino-group; or R⁴ and R⁶ taken in common form a simple bond; A represents oxygen atom or methylene group; n = 0 or 1; Y represents oxygen atom pr NH-group. Compounds elicit the excellent antiviral activity and useful as a therapeutic agent in treatment of viral infections. Also, invention describes a pharmaceutical composition based on compounds of the formula (I) and derivatives of fluoropyrazine carboxamide as intermediate compounds used in synthesis of compounds of the formula (I).

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

13 cl, 6 tbl, 57 ex