FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention describes glycine-substituted thieno[2,3-D]-pyrimidines of the formula (I): 
wherein X represents oxygen atom (O) or H,H; A represents sulfur atom (S), -NH, -N(R6), O or a bond; R1 represents (C1-C4)-alkyl, (C2-C4)-alkenyl, unsubstituted or substituted phenyl, thienyl, pyridyl; R2 represents hydrogen atom (H), (C1-C4)-alkyl, (C1-C4)-alkoxy-(C2-C4)-alkyl or hydroxy-(C2-C4)-alkyl; R3 and R4 are chosen independently from H, (C1-C4)-alkyl and hydroxy-(C1-C4)-alkyl; R5 represents H or (C1-C4)-alkyl, and R6 represents (C1-C4)-alkyl. Compound possess agonistic activity with respect to glycoprotein hormone, in particular, to compounds possessing agonist activity with respect to luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Also, invention describes pharmaceutical compositions containing such compounds and using these compounds in medicinal therapy, in particular, for fertilization control.
EFFECT: valuable biological and medicinal properties of compounds.
11 cl, 1 tbl, 27 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BICYCLIC HETEROAROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING | 2001 |
|
RU2271360C2 |
| DERIVATIVES OF THIENO[2,3-D]PYRIMIDINE AND THEIR USING IN TREATMENT OF FERTILITY DISORDER | 2002 |
|
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| SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK, THEIR PREPARATION AND USE IN TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASES | 2014 |
|
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| INHIBITING JAK COMPOUNDS BASED ON PYRAZOLOPYRIMIDINE AND METHODS | 2010 |
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| NEW SUBSTITUTED BIARYL COMPOUNDS AS INDOLAMINE-2,3-DIOXYGENASE (IDO) INHIBITORS | 2018 |
|
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| CERTAIN PROTEIN KINASE INHIBITORS | 2015 |
|
RU2671494C2 |
