VALSARTAN-BASE SOLID ORAL DOSING FORMULATIONS Russian patent published in 2007 - IPC A61K31/41 A61K9/16 A61K9/20 

FIELD: pharmaceutical technology, pharmacy, drugs.

SUBSTANCE: invention relates to valsartan-base solid formulation. Method involves addition of active component comprising the effective dose of valsartan or its pharmaceutically acceptable salt taken in the amount above 35 wt.-% as measured for the total mass of solid oral dosing formulation to the composition of solid oral dosing formulation prepared by a method carrying out in the absence of water, and pharmaceutically acceptable additives are milled. Mixture of milled active component and additive is pressed to obtain a compressed substance that is converted to granulate followed by its pressing to obtain a solid oral dosing formulation. Proposed technology and processes provide preparing a solid oral dosing formulation with high charge of valsartan and with less required amount of active substance.

EFFECT: improved preparing method.

24 cl