SOLID ORAL DOSAGE FORMS OF VALSARTAN Russian patent published in 2012 - IPC A61K9/20 A61K31/41 A61P9/12 A61K31/549 

FIELD: medicine.

SUBSTANCE: present invention refers to medicine and describes a method for preparing a tablet exhibiting antihypertensive activity containing a) an active substance containing valsartan 80 or 160 mg or its pharmaceutically acceptable salt, and hydrochlorothiazide (HCTZ) 12.5 or 25 mg; b) pharmaceutical acceptable additives suitable for preparing tablets by compression wherein said method involves the stages, I) grinding of the active substance which contains said valsartan and said hydrochlorothiazide, and pharmaceutically acceptable additives; II) compression of a mixture of the grinded active substance and additives with making a comprimate with said compression for making the comprimate requires compaction of the dry mixture of the grinded ingredients; III) transformation of the comprimate into a granulate having a particle size distribution 9 to 340 micron; and IV) compression of the granulate with preparing the tablet.

EFFECT: method provides preparing the tablet possessing intensified antihypertensive activity.

4 cl, 3 ex