FIELD: organic chemistry, medicine, gastroenterology, pharmacy.
SUBSTANCE: invention describes derivatives of imidazopyridine of the general formula (I):
or their pharmaceutically acceptable salts wherein R1 represents hydrogen atom (H), CH3 or CH2OH; R2 represents CH3 or CH2CH3; R3 represents hydrogen atom (H) or (C1-C6)-alkyl; R4 represents hydrogen atom (H) or (C1-C6)-alkyl; R5 represents hydrogen atom (H) or halogen atom; R6 and R7 represent independently hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl, (C1-C6)-alkoxy-substituted (C1-C6)-alkyl, halogenated (C1-C6)-alkyl, phenyl substituted possibly with one substituent or more substituents taken among (C1-C6)-alkyl, (C1-C6)-alkoxy-group, [(C1-C6)-alkyl]2-N-group or NH2SO2, (C1-C6)-alkyl substituted with aryl wherein aryl represents phenyl, imidazolyl possibly substituted with one or more substituent taken among (C1-C6)-alkoxy-group or OH, R8-(C1-C6)-alkyl- wherein R8 represents NH2C=O-, (C1-C6)-alkyl-NHC=O-, [(C1-C6)-alkyl)]2-NC=O-, (C1-C6)-alkyl-OOC- and others under condition that at least one radical among R6 and R7 can't represent hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl or (C1-C6)-alkoxy-substituted (C1-C6)-alkyl; X represents NH or oxygen atom (O), and to intermediate compounds and pharmaceutical preparations based on thereof. Invention relates also to a method for inhibition of secretion of gastric acid and a method for treatment of states associated with H. pylori infection. New compounds inhibit secretion of gastric acid secretion stimulating under exogenous or endogenous conditions and they can be used therefore for prophylaxis and treatment of gastroenteric inflammatory diseases.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
15 cl, 85 ex
| Title | Year | Author | Number |
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