FIELD: medicine, experimental pharmacology.
SUBSTANCE: toxic hepatitis in mice and rats should be reproduced due to intra-gastric introduction of tetrachlorocarbon upon olive oil. Therapy should be fulfilled due to subcutaneous injecting recombinant human granulocytic colony-stimulating factor (CSF) The preparation should be injected at the dosage of about 100-125 mcg/kg once/d daily, for 5 d. The innovation provides stimulation, mobilization, migration and determined homing of mesenchymal stem cells into the liver followed by their differentiation into mature hepatocytes and, as a result, the reconstruction of functionally active hepatic tissue.
EFFECT: higher efficiency of therapy.
1 ex, 4 tbl
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| METHOD OF INCREASING STEM CELLS MOBILIZATION | 2009 |
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| METHOD FOR INCREASE OF STEM CELLS RESERVE IN ORGANISM | 2007 |
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| MEDICATION FOR REGENERATIVE MEDICINE | 2009 |
|
RU2406528C2 |
| HEPATOPROTECTOR | 2010 |
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| METHOD OF CORRECTING, CAUSED BY CYTOSTATIC IMPACT | 2009 |
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| METHOD OF GRANULOCYTOPENIA-STIMULATING EFFECT EVALUATION FOR PHARMACOLOGICAL SUBSTANCES | 2006 |
|
RU2332667C1 |
| METHOD FOR CARRYING OUT EXPERIMENTAL MYOCARDIAL INFARCTION THERAPY | 2005 |
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RU2288738C2 |
