COMBINATION OF PYRIMIDYLAMINOBENZAMIDE AND IMANITIB DERIVATIVES FOR TREATMENT OR PREVENTION OF PROLIFERATIVE DISEASES Russian patent published in 2011 - IPC A61K31/506 A61P35/00

Abstract RU 2430727 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: there is presented a group of inventions including application of a combination of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazole-1-yl)-3 (trifluoromethyl)phenyl]benzamide or its pharmaceutically acceptable salt, and imanitib or its pharmaceutically acceptable salt for preparing a drug intended for a method of treating gastrointestinal (G-I) stromal tumours.

EFFECT: use of the given combination for treating GI stromal tumours is clinically significant as opposed to single agent therapy due to a synergic effect of the preparations to ensure thereby a stable disease.

2 cl, 1 ex, 1 tbl

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RU 2 430 727 C2

Authors

Olland Lila

Manli Pol U.

Mestan Jurgen

Dates

2011-10-10—Published

2006-06-02—Filed