FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to the use of pyrimidylaminobenzamide derivatives, particularly 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]benzamide of formula
, or its pharmaceutically acceptable salt for preparing drugs applicable for treating and preventing systemic mastocytosis. The invention refers to a drug, a method of treating or preventing systemic mastocytosis. The invention also refers to a combination to be used for treating systemic mastocytosis containing the compound of formula (II) and imanitib taken in a therapeutically efficient amount.
EFFECT: compound (II) and combination are applicable in treating systemic mastocytosis which is characterised by resistance to imanitib and preferentially bound with FIPlLl-PDGFRa hybrid gene.
12 cl, 1 ex
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