FIELD: organic chemistry.
SUBSTANCE: invention relates to new compounds of general formula II 
, wherein X, Y represent N; Z O; Ar1 represents 2-piridyl; Ar2 represents phenyl and at least one from Ar1 and Ar2 is substituted by at least one residue selected from group comprising of -F, -Cl, -Br, -I, -SR, -CN, -C(O)R, -CH(OR)R', -CH2(OR), -CF3, C1-C10-alkyl and aryl, wherein R of R' are H, -CF3, C1-C10-alkyl and aryl or together form a ring, except for 3-(2-piridyl)-5-(2-chlorophenyl)-1,2,4-oxadiazole or 3-(2-piridyl)-5-[3-(trifluotomethyl)phenyl]-1,2,4-oxadiazole; or to new compounds as defined in specification; as well as pharmaceutical composition having activity in relation to metabothrophic glutamate receptors based on the same and method for modulating of metabothrophic glutamate receptors.
EFFECT: new compounds useful as modulators of metabothrophic glutamate receptors.
14 cl, 10 ex, 1 dwg
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