PYRROLODINYL ALKYLAMIDE DERIVATIVES, THEIR OBTAINING AND THERAPEUTIC APPLICATION AS LIGANDS OF CCR3 RECEPTOR Russian patent published in 2014 - IPC C07D513/04 C07D417/12 A61K31/428 A61K31/429 A61K31/4353 A61K31/5377 A61K31/4985 A61K31/496 A61P11/06 A61P11/02 A61P17/00 A61P1/04 A61P31/18 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula or , where Ar¹ represents phenyl group, optionally substituted with one or several identical or non-identical halogen atoms; R¹ represents hydrogen atom; R⁴, R⁵, R^6a, R^6b represent hydrogen atoms; Y, Z independently represent linear C_1-4 alkylene group, optionally substituted with one linear C_1-4 alkyl group; Ar² stands for condensed with benzene 5-membered heterocyclic ring, containing one nitrogen atom and one sulphur atom, substituted with one linear C_1-4 alkyl group, or derivative of 5- or 6-membered heterocyclic ring, containing one nitrogen atom and one sulphur atom, condensed with heteroaromatic 6-memebered ring, containing one or two nitrogen atoms, substituted with one linear C_1-4 alkyl group, linear C_1-4 alkoxygroup or group -NR⁷R⁸, where R⁷ and R⁸ independently stand for hydrogen atom, linear or branched C_1-4 alkyl group, or R⁷ and R⁸ together with nitrogen atom form group of general formula , where R², R³ represent linear C_1-4 alkyl groups, A stands for group -CHR¹², oxygen atom or group -NR⁹, where R¹² and R⁹ stand for hydrogen atom or linear C_1-4 alkyl group, m has value 1 or 2, n has value 1 or 2, o has value 0 or 1, p has value 0 or 1, Q stands for group -O^-, group -N^--H or group -N^--CO-R¹⁰, where R¹⁰ stands for linear C_1-4 alkyl group or -NH-R¹¹ group, where R¹¹ represents linear C_1-4 alkyl group; and to their salts. Invention also relates to methods of obtaining therein and to based on them pharmaceutical composition, possessing antagonistic activity with respect to receptor CCR3.

EFFECT: obtained are novel compounds and based on them pharmaceutical compositions, which can be applied in medicine for obtaining medication, intended for treating asthma, allergic rhinitis, atopic dermatitis, eczema, inflammatory intestinal diseases, ulcerous colitis, Crohn's disease, allergic conjunctivitis, multiple sclerosis or HIV-infection and AIDS-associated diseases.

14 cl, 3 tbl, 26 ex