POLYHETEROCYCLIC COMPOUNDS AND USE THEREOF AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS Russian patent published in 2010 - IPC C07D413/14 C07D403/14 C07D401/14 A61K31/4523 A61K31/5377 A61K31/496 A61P25/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula I and their pharmaceutically acceptable salts which have inhibitory properties towards mGluR5. In formula I , P represents phenyl; R¹ is bonded to P through a carbon atom on ring P and is selected from a group consisting of halogen, C_1-6alkylhalogen, OC_1-6alkylhalogen, C_1-6alkyl, OC_1-6alkyl and C_0-6alkylcyano; X¹ is selected from a group consisting of N, NR⁴ and CR⁴; X² is selected from a group consisting of C and N; X³ is selected from a group consisting of N and O; X⁴ is selected from a group consisting of N and O; X⁵ is selected from a group consisting of a bond, CR⁴R⁴', NR⁴, O, S, SO, SO₂; X⁶ represents N; X⁷ is selected from a group consisting of C and N; Q represents triazolyl.

EFFECT: invention also relates to a pharmaceutical composition containing a therapeutically effective amount of the disclosed compound as an active ingredient, use of the compound in making a medicinal agent for treating disorders mediated by mGluR5 and to a method of inhibiting activation of mGluR5 receptors.

25 cl, 82 ex