DERIVATIVES (INDOLE-3-YL) HETEROCYCLIC COMPOUNDS AS AGONISTS OF CANNABINOID RECEPTORS CB1 Russian patent published in 2009 - IPC C07D413/14 C07D417/04 C07D498/02 A61K31/4245 A61P29/00 

FIELD: medicine.

SUBSTANCE: invention is related to new derivatives (indole-3-yl)heterocyclic compounds of formula 1: , where: A represents 5-member aromatic heterocyclic ring, where X₁, X₂ and X₃ are independently selected from N, O, S, CR; R means H, (C_1-4)alkyl; or R, when it is available in X₂ or X₃, may form 5-8-member ring together with R₃; R₁ means 5-8-member saturated carbocyclic ring, which unnecessarily contains heteroatom O; R₂ means H; or R₂ is connected to R₇ with creation of 6-member ring, which unnecessarily contains heteroatom O, or where mentioned heteroatom is connected to position 7 of indole ring; R₃ and R₄ independently mean H, (C_1-6)alkyl, which is unnecessarily substituted with OH, (C_1-4)alkyloxy; or R₃ together with R₄ and N, with which they are connected, creates 4-8-member ring, which unnecessarily contains additional heteroatom, selected from O and S, and unnecessarily substituted with OH, (C_1-4)alkyl, (C_1-4)alkyloxy or (C_1-4)alkyloxy-(C_1-4)alkyl; or R₃ together with R₅ creates 4-8-member ring, unnecessarily substituted with OH, (C_1-4)alkyl, (C_1-4)alkyloxy; or R₃ together with R, when present in X₂ or X₃, creates 5-8-member ring; R₅ means H; or R₅ together with R₃ creates 4-8-member ring, unnecessarily substituted with OH, (C_1-4)alkyl, (C_1-4)alkyloxy; R_5' means H; R₆ means one substituent selected from H, (C_1-4)alkyl, (C_1-4)alkyloxy, halogen; R₇ means H, (C_1-4)alkyl, (C_1-4)alkyloxy, halogen; or R₇ is connected to R₂ with creation of 6-member ring, which unnecessarily contains additional heteroatom O, and where heteroatom is connected to position 7 of indole ring; or its pharmaceutically acceptable salt. Compounds of formula I display activity of agonists to cannabinoid receptor CB1.

EFFECT: possibility to use them for treatment of pains of various nature.

10 cl, 1 tbl, 42 ex