QUINUCLIDINE CARBAMATES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2007 - IPC C07D453/02 A61K31/439 A61P1/00 A61P13/00 A61P31/06 

Abstract RU 2296762 C2

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to novel derivatives of carbamate of the formula (I): or to their pharmaceutically acceptable salts wherein R1 represents compounds of formulas: , , , ,

, , , or ; R3 means hydrogen, halogen atom or alkyl; R2 means benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophene-2-ylmethyl, thiophene-3-ylmethyl or alkyl; p = 1 or 2, and substitution in azabicyclic ring can be at position 2, 3 or 4. Compounds of the formula (I) and their salts possess inhibitory activity with respect to muscarinic M3 receptors and can be used in medicine.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.

25 cl, 1 tbl, 165 ex

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RU 2 296 762 C2

Authors

Buil Al'Bero Marija Antonija

Fernandes Forner Marija Dolors

Prat Kin'Ones Marija

Dates

2007-04-10Published

2001-12-20Filed