FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention relates to novel derivatives of carbamate of the formula (I): or to their pharmaceutically acceptable salts wherein R1 represents compounds of formulas: , , , ,
, , , or ; R3 means hydrogen, halogen atom or alkyl; R2 means benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophene-2-ylmethyl, thiophene-3-ylmethyl or alkyl; p = 1 or 2, and substitution in azabicyclic ring can be at position 2, 3 or 4. Compounds of the formula (I) and their salts possess inhibitory activity with respect to muscarinic M3 receptors and can be used in medicine.
EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.
25 cl, 1 tbl, 165 ex
Authors
Dates
2007-04-10—Published
2001-12-20—Filed