HINUCLIDINE ETHERS OF 1-AZAHETEROCYLIC ACETIC ACID AS ANTIMUSCARINE MEANS, METHOD FOR THEIR PRODUCTION AND THEIR DRUG COMPOSITIONS Russian patent published in 2017 - IPC C07D453/02 C07D401/12 C07D413/12 C07D417/12 A61K31/439 A61P11/08 

FIELD: pharmacology.

SUBSTANCE: invention relates to formula compounds, where A can be a single bond, a double bond, O, S, NR₃, C(R₃)R₄, CO, C(O)N(R₃), N(R₃)C(O) and C(R₃)-(CH₂)-C(R₄); m is an integer from 1 to 4; N is 0 or an integer from 1 to 4; R1 is selected from the group consisting of phenyl and 5-member heteroaryl containing one S heteroatom optionally substituted by one or more substituents selected from the group consisting of halogen atoms, (C₁-C₆)alkyl and (C₁-C₆)alkoxy; X is a physiologically acceptable anion; R2 is a group of the formula (Y), where p is 0 or an integer from 1 to 4; Q is 0 or an integer from 1 to 4; P is absent or selected from the group consisting of CO, N(R₃)C(O) and C(O)N(R₃); W is selected from the group consisting of H, (C₁-C₁₀)alkoxyl, phenyl, heteroaryl optionally substituted with one or more substituents selected from the group consisting of halogen atoms, OH, oxo (=O), CO₂R₃, (C₁-C₆)alkyl, (C₁-C₆)alkoxyl and phenyl; wherein heteroaryl is a mono- or bicyclic ring system having from 5 to 9 ring atoms and from 1 to 3 heteroatoms selected from N, O and S; R3 and R4 are independently selected from the group consisting of H, halogen atoms, CONH₂, (C₁-C₆)alkyl, (C₁-C₆)alkanoyl and (C₃-C₈)cycloalkyl, as selective M3 receptor antagonists, to a method for their preparation, to compositions containing them, and to their therapeutic use for treatment of a respiratory disease such as asthma and chronic obstructive pulmonary disease (COPD).

EFFECT: increased composition application efficiency.

14 cl, 2 tbl, 34 ex