DERIVATIVES OF QUINUCLIDINE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2006 - IPC C07D453/02 A61K31/439 A61P1/00 A61P13/00 A61P31/06 

FIELD: organic chemistry, pharmacology, pharmacy.

SUBSTANCE: invention relates to derivatives of quinuclidine of the general formula (I): wherein B means phenyl, pyrrolyl and other group; each among R¹, R² and R³ represents hydrogen, halogen atom, phenyl group and others; n means a whole number from 0 to 4; A represents the group chosen from -CH₂-, -CH=CR⁹, -CR⁹R¹⁰ and others wherein R⁹ and R¹⁰ represent hydrogen atom or (C₁-C₈)-alkyl; m means a whole number from 0 to 8 under condition that if m = 0 then A doesn't mean -CH₂-; p means a whole number from 1 to 2; R⁴ represents phenyl or 5-membered heteroaromatic cycle comprising oxygen or sulfur atom; R⁵ represents (C₁-C₇)-alkyl, (C₂-C₇)-alkenyl, (C₂-C₇)-alkynyl and others; R⁶ represents hydrogen atom, hydroxy-group and others; X^- represents a pharmaceutically acceptable anion of mono- or polyvalent acid. Compounds of the formula (I) possess the inhibitory activity with respect to M3-muscarinic receptors and can be used in medicine.

EFFECT: improved preparing method, valuable medicinal properties of compounds and composition.

34 cl, 2 tbl, 104 ex