METHOD FOR PREPARING 2-(3',5'-DIAMINO-1',2',4'-TRIAZOL-1'-YL)-4-R-5-R-1,3-THIAZOLES Russian patent published in 2007 - IPC C07D417/04 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to an improved method for synthesis of 2-(3',5'-diamino-1',2',4'-triazol-1'-yl)-4-R¹-5-R²-1,3-thiazoles of the general formula (I): , wherein R¹ represents hydrogen atom (H), direct or branched (C₁-C₄)-alkyl or COO-(C₁-C₄)-alkyl or phenyl optionally substituted with one or some substitutes chosen from halogen atom; R² represents H, direct or branched (C₁-C₄)-alkyl, COO-(C₁-C₄)-alkyl. Method for synthesis involves addition to aqueous solution of 4-R¹-5-R²-1-hydrazino-1,3-thiazole hydrochloride of the formula (II): , wherein R¹ and R² have above given values of N-cyanoguanidine of the formula (III): in the mole ratio (II) : (III) = (1.10-1.20):100. Prepared mixture is heated at temperature 80-95°C followed by its neutralization, filtering off and recrystallization. Method provides preparing 2-(3',5'-diamino-1',2',4'-triazol-1'-yl)-4-R¹-5-R²-1,3-thiazole from inexpensive and available raw and without using complex technological procedures. Synthesized compounds can be used in synthesis of medicinal and biologically active substances.

EFFECT: improved method of synthesis.

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