METHOD FOR PREPARING 5-AMINO-1,2,4-TRIAZOL-3-YLCARBOXYLIC ACID AMIDES Russian patent published in 2007 - IPC C07D249/14 C07D403/06 C07D413/06 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention describes a method for synthesis of novel carboxylic acid amides of the general formula (I):

wherein R¹ represents hydrogen atom (H); R² represents a linear or branched (C₁-C₈)-alkyl possibly substituted with phenyl; or R¹ and R² in common with nitrogen atom (N) represent a 5-membered heterocyclic residue or a 6-membered heterocyclic residue comprising oxygen atom additionally; n = 0, 1. Method involves heating a mixture of 5-amino-1,2,4-triazol-3-ylcarboxylic acid ester of the general formula (II):

wherein R³ represents (C₁-C₄)-alkyl group; n = 0, 1, amine of the general formula (III):

wherein R¹ and R² have value given above and tertiary aliphatic amine of the formula (IV) given in the invention description at temperature 70-130°C wherein components are taken in the ratio (II) : (III) : (IV) = 1.0:(1.1-2.5):(1.0-3.0), respectively. Method provides decreasing the cost of compounds of the formula (I) based on using the more inexpensive raw, reducing duration of the process and enhancing safety of the process. Synthesized compounds can be used in synthesis of biologically active substances and dyes.

EFFECT: improved method of synthesis, valuable properties of compounds.

2 cl, 6 ex