FIELD: chemistry of proteins, virology, pharmacy.
SUBSTANCE: invention relates to novel physiologically active protein conjugates that can be used in medicine. Proposed conjugates is formed by a protein molecule and polyethylene glycol and corresponds to the formula: wherein protein represents interferon α-2b; n and n1 have values providing an average molecular mass of links from about 7500 Da to about 35000 Da. Conjugate shows the enhanced stability as compared with the known analogs. Also, invention relates to a pharmaceutical composition possessing an antiviral activity and containing the indicated conjugate, and to a method for control of viral infection.
EFFECT: valuable medicinal and biological properties of conjugates.
4 cl, 1 dwg, 6 ex
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Authors
Dates
2007-05-10—Published
2004-04-30—Filed