CONJUGATES OF PROTEIN AND POLYETHYLENE GLYCOL DERIVATIVE, PHARMACEUTICAL COMPOSITION, METHOD FOR CONTROL OF VIRAL INFECTION Russian patent published in 2007 - IPC C07K14/56 A61K38/21 A61K31/787 A61P31/12 

Abstract RU 2298560 C2

FIELD: chemistry of proteins, virology, pharmacy.

SUBSTANCE: invention relates to novel physiologically active protein conjugates that can be used in medicine. Proposed conjugates is formed by a protein molecule and polyethylene glycol and corresponds to the formula: wherein protein represents interferon α-2b; n and n1 have values providing an average molecular mass of links from about 7500 Da to about 35000 Da. Conjugate shows the enhanced stability as compared with the known analogs. Also, invention relates to a pharmaceutical composition possessing an antiviral activity and containing the indicated conjugate, and to a method for control of viral infection.

EFFECT: valuable medicinal and biological properties of conjugates.

4 cl, 1 dwg, 6 ex

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RU 2 298 560 C2

Authors

Kurochkin Sergej Nikolaevich

Parkanskij Anton Aleksandrovich

Chibiljaev Timur Khajdarovich

Dates

2007-05-10Published

2004-04-30Filed