FIELD: medicine.
SUBSTANCE: medicinal agent with activity of alpha interferon represents a conjugate with a molecule of branched polyethylene glycol of general formula: 
, where: INF - polypeptide of alpha interferon; R - radicals of 2-aminoethanol -HN-CH2-CH2-O-, 3-aminopropanol -HN-CH2-CH2-CH2-O-, homoserine -HN-CH(COOH)-CH2-CH2-O-; n and n1 - identical or different =50-170, wherein residual branched polyethylene glycol molecular weight 5000-15000 Da are covalently bound with amino groups of polypeptide of alpha interferon.
EFFECT: said agent is an effective antiviral and antiproliferative preparation.
2 cl, 3 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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|
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|
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|
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| ERYTHROPOETIN APPLICATION | 2003 |
|
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| CONJUGATE OF GLYCOPROTEIN, POSSESSING ERYTHROPOIETIN ACTIVITY, WITH POLY-1,4-ETHYLENEPIPERAZINE N-OXIDE DERIVATIVES (VERSIONS), PHARMACEUTICAL COMPOSITION AND METHOD OF CONJUGATE OBTAINING | 2013 |
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RU2556378C2 |
| INTERFERON CONJUGATES AND METHOD FOR PRODUCTION THEREOF | 2011 |
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RU2288212C2 |
