FIELD: medicine.
SUBSTANCE: medicinal agent with activity of alpha interferon represents a conjugate with a molecule of branched polyethylene glycol of general formula: 
, where: INF - polypeptide of alpha interferon; R - radicals of 2-aminoethanol -HN-CH2-CH2-O-, 3-aminopropanol -HN-CH2-CH2-CH2-O-, homoserine -HN-CH(COOH)-CH2-CH2-O-; n and n1 - identical or different =50-170, wherein residual branched polyethylene glycol molecular weight 5000-15000 Da are covalently bound with amino groups of polypeptide of alpha interferon.
EFFECT: said agent is an effective antiviral and antiproliferative preparation.
2 cl, 3 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PAGYLATED INTERFERON AGAINST VIRAL INFECTION | 2004 |
|
RU2311930C2 |
| CONJUGATES OF PROTEIN AND POLYETHYLENE GLYCOL DERIVATIVE, PHARMACEUTICAL COMPOSITION, METHOD FOR CONTROL OF VIRAL INFECTION | 2004 |
|
RU2298560C2 |
| NOVEL FUNCTIONALLY ACTIVE, HIGHLY PURE, STABLE CONJUGATE OF INTERFERON α WITH POLYETHYLENE GLYCOL, REPRESENTED BY ONE PEG- NH-IFN POSITIONAL ISOMER, WITH IMPROVED IMMUNOGENICITY, WITH PROLONGED BIOLOGICAL ACTION, SUITABLE FOR MEDICAL APPLICATION, AND IMMUNOLOGICAL AGENT BASED THEREON | 2010 |
|
RU2447083C1 |
| PEG DENDRIMER WITH FOUR BRANCHES FOR CONJUGATION WITH PROTEINS AND PEPTIDES | 2006 |
|
RU2409389C2 |
| WATER-SOLUBLE HYDROLYTICALLY STABLE ACTIVATED POLYMER, METHOD OF SYNTHESIS OF ACTIVATED POLYETHYLENE GLYCOL (VARIANTS), BIOLOGICALLY ACTIVE CONJUGATE | 1994 |
|
RU2176253C2 |
| ERYTHROPOETIN APPLICATION | 2003 |
|
RU2305554C2 |
| PEG-CONTAINING CONJUGATES OF HGF-NK4 | 2002 |
|
RU2293574C2 |
| INTERFERON CONJUGATES AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2466138C1 |
| CONJUGATE OF GLYCOPROTEIN, POSSESSING ERYTHROPOIETIN ACTIVITY, WITH POLY-1,4-ETHYLENEPIPERAZINE N-OXIDE DERIVATIVES (VERSIONS), PHARMACEUTICAL COMPOSITION AND METHOD OF CONJUGATE OBTAINING | 2013 |
|
RU2556378C2 |
| DERIVATIVES OF POLYETYLENE GLYCOL ALDEHYDE | 2003 |
|
RU2288212C2 |
