FIELD: biochemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to novel using inhibitors of dipeptidyl peptidase IV (DPIV) - isoleucylthiazolidine, isoleucylcyanopyrrolidine and valylpyrrolidine and their corresponding pharmaceutically acceptable acid-additive salts used in treatment and prophylaxis of colony-forming tumor cells and/or metastasis. Enumerated compounds decreased adhesion of rat tumor pulmonary cells and resulted to decrease amount of colonies of tumor cells in them and reduced metastasis.
EFFECT: valuable medicinal anticancer properties of inhibitors.
3 cl, 6 dwg, 8 ex
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