FIELD: biochemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to novel using inhibitors of dipeptidyl peptidase IV (DPIV) - isoleucylthiazolidine, isoleucylcyanopyrrolidine and valylpyrrolidine and their corresponding pharmaceutically acceptable acid-additive salts used in treatment and prophylaxis of colony-forming tumor cells and/or metastasis. Enumerated compounds decreased adhesion of rat tumor pulmonary cells and resulted to decrease amount of colonies of tumor cells in them and reduced metastasis.
EFFECT: valuable medicinal anticancer properties of inhibitors.
3 cl, 6 dwg, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW DIPEPTIDYL PEPTIDASE IV INHIBITORS AND USES THEREOF AS HYPOTENSIVE AGENT | 2002 |
|
RU2305553C2 |
| METHOD FOR TREATING PATIENTS FOR NEUROLOGICAL AND NEUROPSYCHOLOGICAL DISORDERS | 2001 |
|
RU2286149C2 |
| METHOD FOR TREATING NEUROLOGICAL AND NEURO-PSYCHOLOGICAL MALFUNCTIONS | 2006 |
|
RU2416406C2 |
| NOVEL APPROACH TO CANCER TREATMENT USING IMMUNOMODULATION | 2016 |
|
RU2817047C2 |
| EXENATIDE ANALOGUE | 2020 |
|
RU2823623C1 |
| COMPOSITION FOR TREATING IGF-1R EXPRESSING CANCER | 2016 |
|
RU2728568C2 |
| ANTIBODY TO B7H3-EXATECAN ANALOGUE CONJUGATE AND ITS USE IN MEDICINE | 2019 |
|
RU2785664C2 |
| EFFECTORS OF DIPEPTIDYL PEPTIDASE IV | 1999 |
|
RU2309161C2 |
| ANTIBODY-DRUG CONJUGATE TARGETING TROP2, AND METHOD FOR PREPARING AND USING SAME | 2020 |
|
RU2822663C1 |
| METHODS FOR DETERMINING DPP3 AND THERAPEUTIC METHODS | 2017 |
|
RU2771824C2 |
