1-HETEROCYCLYLSULPHONYL, 2-AMINOMETHYL, 5-(HETERO)ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION INHIBITORS Russian patent published in 2011 - IPC C07D207/48 C07D401/04 C07D409/04 A61K31/40 A61P1/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compound described by formula where R¹ represents a monocyclic nitrogen-containing heterocyclic group optionally condensed with heterocycle with the monocyclic nitrogen-containing heterocyclic group optionally condensed with heterocycle, optionally having 1 to 5 substitutes chosen from a group consisting of (1) halogen atom, (2) cyano, (3) hydroxy, (4) C_1-6 alkoxy optionally having 1 to 3 halogen atoms, (5) amino, (6) mono- C_1-6 alkylamino, (7) C_1-6 alkoxycarbonyl and (8) C_1-6 alkyl optionally having 1 to 3 halogen atoms, R² represents (i) C_6-14 aryl group optionally substituted by 1 to 5 substitutes chosen of a group consisting of (1) halogen atom, (2) cyano, (3) C_1-6 alkoxy optionally having 1 to 3 halogen atoms, (4) C_1-6 alkylthio optionally having 1 to 3 halogen atoms, (5) C_1-6alkylcarbonyl, (6) C_1-6 alkylsulphonyl, (7) C_1-6 alkylthionyl, (8) C_3-7 cycloalkyl, (9) C_1-6 alkyl group optionally having 1 to 3 halogen atoms, and (10) C_1-6 alkyl group substituted by 1 to 3 hydroxy, (ii) a thienyl group optionally substituted by 1 to 4 substitutes chosen from a group consisting of (1) cyano and (2) C_1-6 alkyl group optionally having 1 to 3 halogen atoms, (iii) a pyridyl group optionally substituted by 1 to 4 substitutes chosen from a group consisting of (1) halogen atom, (2) 5-10-members aromatic heterocyclic group containing carbon atom, and 1 or 2 presentations of 1-4 heteroatoms chosen from nitrogen atom, sulphur atom and oxygen atom, and (3) C_1-6 alkyl group optionally having 1 to 3 halogen atoms, or (iv) a bipyridyl group optionally substituted by 1 to 3 halogen atoms, each R³ and R⁴ represents hydrogen atom, or one of R³ and R⁴ represents hydrogen atom, and another represent a lower alkyl group, halogen atom or a cyanogroup, and R⁵ represents an alkyl group, or to its salt. Also, the invention refers to a pharmaceutical composition showing an acid secretion inhibitory effect enabled by the compound of formula I, to a method for treatment or prevention, besides, to application of the compound of formula I for preparing a pharmaceutical composition for treatment or prevention of a number of diseases presented in the patent claim.

EFFECT: preparation of the new compounds showing the acid secretion inhibitory effect and exhibiting antiulcerant action.

20 cl, 92 ex, 24 tbl