FIELD: organic chemistry, medicine, ophthalmology, pharmacy.
SUBSTANCE: invention relates to novel derivatives of benzo[g]quinoline of the formula (I): 
as a free base or acid-additive salt used in treatment of glaucoma and myopia, and to a method for their synthesis and a pharmaceutical composition. In compound of the formula (I) each A and B means hydrogen atom (H); X means -CH2; Y means sulfur atom (S); R1 means H or (C1-C4)-alkyl wherein this compound can be in form of a free base or acid-additive salt. Method for synthesis of compound of the formula (I) by claim 1 or its salt involves the conversion step of alkoxy-group in compound of the formula (II): 
wherein A, B, X, Y and R1 have values given in claim 1; R3 means (C1-C4)-alkyl to hydroxy-group, and conversion of synthesized compounds of the formula (I) to free base or its acid-additive salt.
EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.
7 cl, 1 ex
| Title |
Year |
Author |
Number |
| QUINOLINE DERIVATIVES |
2003 |
- Gull' Peter
- Pombo-Vil'Jar Ehsteban
|
RU2345991C2 |
| NEW CATECHOLAMINE-BASED PRODRUGS FOR USE IN TREATMENT OF PARKINSON'S DISEASE |
2018 |
- Jensen Klaus Gervig
- Kvaerno Lisbet
- Dzhukhl Martin
- Jorgensen Morten
|
RU2806075C2 |
| BENZO(G)QUINOLINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND METHOD OF TREATMENT |
1996 |
- Nojmann Peter
- Pfeffli Paul'
- Zajler Maks Peter
- Svoboda Robert
|
RU2158738C2 |
| NOVEL SOLID FORMS (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID |
2020 |
- Jensen, Klaus, Gervig
- Jorgensen, Morten
- Dzhukhl, Martin
- Kvaerno, Lisbet
- De Diego, Khejdi, Lopez
- Fredkholt, Karin
- Terkelsen, Frans Dennis
- Frikhed, Tobias Gilling
- Yakobsen, Mikkel Fog
|
RU2820501C2 |
| PYRROLIDINIUM DERIVATIVES AS M3 MUSCARINIC RECEPTORS |
2005 |
- Press Nejl Dzhon
- Kollingvud Stiven Pol
|
RU2412183C2 |
| AZABICYCLOALKYL ETHERS AND THEIR APPLICATION AS ALPHA7-nAChR AGONISTS |
2003 |
- Fojerbakh Dominik
- Khurt Konstantse
- Ritchi Timoti Dzhon
|
RU2352569C2 |
| BENZO[F]QUINOLINONE, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1995 |
- Dzhejms Ehdmund Audia
- Kevin Li Khehl
- Tomas Dzhozef Kress
- Loretta Ehjms Makkvejd
- Blehjk Li N'Jubauehr
- Vinsent Patrik Rokko
- Dzhejms Patrik Vepsik
|
RU2172312C2 |
| METHOD OF PRODUCING (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND INTERMEDIATE COMPOUNDS FOR ITS PRODUCTION |
2020 |
- Dzhukhl, Martin
- Yakobsen, Mikkel,Fog
- Kvaerno, Lisbet
|
RU2817700C2 |
| METHOD OF PRODUCING (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID |
2020 |
- Dzhukhl, Martin
- Terkelsen, Frans, Dennis
- Frikhed, Tobias, Gilling
|
RU2819919C2 |
| (-AMINO-(-HYDROXY-(-ARYLALKANOIC AMIDES AND USE THEREOF AS RENIN INHIBITORS |
2004 |
- Zell'Ner Khol'Ger
- Gross Gerkhard
- Majbaum Jurgen Klaus
- Kotten Sil'Ven
|
RU2425027C2 |
